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<table cellpadding="0" cellspacing="0" width="100%"><tr><th colspan="2">Entry information</th></tr> <tr><td width="20%">Entry name</td> <td><strong>DNP_DENAN</strong></td></tr> <tr><td>Primary accession</td> <td><strong>P28374</strong></td></tr> <tr...
cGMP via the natriuretic peptide receptor A (NPR1). Is a poor
agonist of the atrial natriuretic peptide receptor B (NPR2). Is
not degradated by neutral endopeptidase (NEP / MME). Binds to
atrial natriuretic peptide clearance receptor (NPR3 / NPR-C),
which may be responsible of the removal of DNP from the
circulation. Increases calcium uptake and induces histamine
release from rat peritoneal mast cells. Increases calcium-
activated potassium current in gastric antral circular smooth
muscle cells by increasing cGMP production and activating inositol
trisphosphate receptors (IP3Rs).
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