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          source {
            {
              src {
                db "MGC" ,
                tag
                  str "BC047666" } ,
              anchor "MGC" ,
              url "http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC047666" } } } } } ,
    {
      type generif ,
      text "In breast, NAT1 mRNA is transcribed from a strong promoter located
 11.8 kb upstream of the translated exon, and the mature spliced mRNA includes
 at least one additional non-coding exon." ,
      version 0 ,
      refs {
        pmid 15226672 } ,
      create-date
        str "Mar 26 2005 10:01AM" ,
      update-date
        str "Mar 26 2005  1:53PM" } ,
    {
      type generif ,
      text "Polymorphism at the NAT1 locus has been associated with the
 existence of at least 26 allelic variants, generating phenotypic variations
 in terms NAT-1 catalytic activity. This genetic variation affects the
 acetylator status of individuals." ,
      version 0 ,
      refs {
        pmid 15320760 } ,
      create-date
        str "Dec 18 2004 10:01AM" ,
      update-date
        str "Mar 17 2005  6:52AM" } ,
    {
      type generif ,
      text "NAT1 exists in the cell in either a stable acetylated state or an
 unstable non-acetylated state and mutations in the NAT1 gene that prevent
 protein acetylation produce a slow acetylator phenotype" ,
      version 0 ,
      refs {
        pmid 15039438 } ,
      create-date
        str "Jul  6 2004 11:50AM" ,
      update-date
        str "Jul  6 2004 12:11PM" } ,
    {
      type generif ,
      text "Analysis of the effect of active NAT-1 overexpression in a normal
 luminal epithelial-derived cell line demonstrated enhanced growth properties
 and etoposide resistance relative to control cells." ,
      version 0 ,
      refs {
        pmid 14517345 } ,
      create-date
        str "Jun 23 2004  4:43PM" ,
      update-date
        str "Jun 23 2004  5:16PM" } ,
    {
      type generif ,
      text "cellular generation of peroxynitrite may contribute to
 carcinogenesis and tumor progression by weakening key cellular defense
 enzymes such as arylamine N-acetyltransferase 1 (NAT1)" ,
      version 0 ,
      refs {
        pmid 14672957 } ,
      create-date
        str "Mar 24 2004 12:00AM" ,
      update-date
        str "May  9 2004  7:01AM" } ,
    {
      type generif ,
      text "although there is little overall association between NAT genotypes
 and risk of developing systemic lupus erythematosus, the interaction between
 NAT1 and NAT2 and specific exposures such as hair dyes may be important." ,
      version 0 ,
      refs {
        pmid 14705222 } ,
      create-date
        str "Apr 16 2004 12:00AM" ,
      update-date
        str "May  2 2004  7:01AM" } ,
    {
      type generif ,
      text "A putative RUNX1 binding site variant of NAT9 is associated with
 susceptibility to psoriasis" ,
      version 0 ,
      refs {
        pmid 14608357 } ,
      create-date
        str "Dec 18 2003 12:00AM" ,
      update-date
        str "Jan 11 2004  7:03AM" } ,
    {
      type generif ,
      text "Identification of minimal promoter sequences for transcription
 factor binding sites in the human N-acetyltransferase Type I gene. that binds" ,
      version 0 ,
      refs {
        pmid 12946272 } ,
      create-date
        str "Nov 24 2003 12:00AM" ,
      update-date
        str "Dec  7 2003  7:02AM" } ,
    {
      type generif ,
      text "Oxidative stress and cellular redox status may regulate NAT1
 activity and have important consequences with regard to drug
 biotransformation and cancer risk." ,
      version 0 ,
      refs {
        pmid 12832400 } ,
      create-date
        str "Oct  7 2003 12:00AM" ,
      update-date
        str "Nov 16 2003  7:02AM" } ,
    {
      type generif ,
      text "Variation in capacity for acetylation of 4ABP and PABA resulting
 from human NAT1 transgene is insufficient to affect 4ABP genotoxicity in
 mouse liver." ,
      version 0 ,