Bio-ASN1-EntrezGene
view release on metacpan or search on metacpan
t/data/entrezgene.dat view on Meta::CPAN
{
src {
db "MGC" ,
tag
str "BC040071" } ,
anchor "MGC" ,
url "http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC040071" } } } } } ,
{
type comment ,
heading "Pathways" ,
version 0 ,
comment {
{
type comment ,
text "KEGG pathway: Alzheimer's disease" ,
version 0 ,
source {
{
src {
db "05010" ,
tag
str "05010" } ,
anchor "05010" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa05010+2" } } } ,
{
type comment ,
text "KEGG pathway: Coagulation cascade" ,
version 0 ,
source {
{
src {
db "04610" ,
tag
str "04610" } ,
anchor "04610" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa04610+2" } } } ,
{
type comment ,
text "KEGG pathway: Complement and coagulation cascades" ,
version 0 ,
source {
{
src {
db "04610" ,
tag
str "04610" } ,
anchor "04610" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa04610+2" } } } ,
{
type comment ,
text "Reactome: Hemostasis" ,
version 0 ,
source {
{
anchor "49292" ,
url "http://www.reactome.org/cgi-bin/link?SOURCE=UniProt&ID=P010
23" } } } } } ,
{
type generif ,
text "an important involvement of alpha2M in regulation of increased
proteolytic activity occurring in multiple sclerosis disease" ,
version 0 ,
refs {
pmid 15511627 } ,
create-date
str "Dec 18 2004 10:01AM" ,
update-date
str "Dec 18 2004 1:19PM" } ,
{
type generif ,
text "alpha2-macroglobulin inhibits human pepsin and gastricsin" ,
version 0 ,
refs {
pmid 14506912 } ,
create-date
str "Oct 7 2003 12:00AM" ,
update-date
str "Jul 7 2004 1:36PM" } ,
{
type generif ,
text "There is a significant genetic association of the 5 bp deletion
and two novel polymorphisms in alpha-2-macroglobulin alpha-2-macroglobulin
precursor with AD" ,
version 0 ,
refs {
pmid 12966032 } ,
create-date
str "Jun 27 2004 5:41PM" ,
update-date
str "Jun 27 2004 6:18PM" } ,
{
type generif ,
text "Alpha2-macroglobulin is a substrate and an endogenous inhibitor
for ADAMTS-4 and ADAMTS-5" ,
version 0 ,
refs {
pmid 14715656 } ,
create-date
str "Jun 14 2004 4:41PM" ,
update-date
str "Jun 14 2004 5:44PM" } ,
{
type generif ,
text "A2M-D allele played a weak Alzheimer disease protective role, and
APOE-E4 and A2M-G alleles might act synergistically in Alzheimer disease risk
for mainland Han Chinese." ,
version 0 ,
refs {
pmid 14675603 } ,
create-date
str "Feb 17 2004 12:00AM" ,
update-date
str "Apr 13 2004 1:35PM" } ,
{
type generif ,
text "Plasma from patients homozygous for the intronic deletion (DD)
showed normal alpha(2)M subunit size, conformation, and proteinase inhibitory
activity. Plasma alpha(2)M from two DD patients showed markedly increased
TGF-beta1 binding." ,
version 0 ,
refs {
t/data/entrezgene.dat view on Meta::CPAN
{
type generif ,
text "relationship between serum VEGF levels, alpha(2)M levels and the
development of OHSS in hyperstimulated subjects undergoing IVF" ,
version 0 ,
refs {
pmid 12042276 } ,
create-date
str "Dec 16 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:00AM" } ,
{
type generif ,
text "Genetic association of alpha2-macroglobulin polymorphisms with
Alzheimer's disease" ,
version 0 ,
refs {
pmid 12221172 } ,
create-date
str "Sep 27 2002 12:00AM" ,
update-date
str "Oct 7 2002 8:10AM" } ,
{
type generif ,
text "Genetic association of argyrophilic grain disease with
polymorphisms in alpha-2 macroglobulin." ,
version 0 ,
refs {
pmid 12175343 } ,
create-date
str "Sep 24 2002 12:00AM" ,
update-date
str "Oct 7 2002 8:10AM" } ,
{
type generif ,
text "The three-dimensional structure of the dimer reveals its
structural organization in the tetrameric native and chymotrypsin alpha
2-macroglobulin complexes." ,
version 0 ,
refs {
pmid 12015318 } ,
create-date
str "Sep 5 2002 12:00AM" ,
update-date
str "Sep 23 2002 6:27AM" } ,
{
type generif ,
text "has an important role in the AD-specific neurodegenerative process
but its exon 24 Val-1000-Ile polymorphism is not likely to be associated with
late-onset sporadic AD in the Hungarian population" ,
version 0 ,
refs {
pmid 11901360 } ,
create-date
str "Aug 6 2002 12:00AM" ,
update-date
str "Aug 28 2002 6:15PM" } ,
{
type generif ,
text "REVIEW: binds and neutralizes alfimeprase, which has direct
proteolytic activity against the fibrinogen Aalpha chain" ,
version 0 ,
refs {
pmid 11910179 } ,
create-date
str "Jun 12 2002 12:00AM" ,
update-date
str "Sep 7 2003 7:01AM" } ,
{
type generif ,
text "distinct binding sites mediate interaction with beta-amyloid
peptide and growth factors" ,
version 0 ,
refs {
pmid 11823454 } ,
create-date
str "May 4 2002 12:00AM" ,
update-date
str "May 18 2002 6:08AM" } ,
{
type generif ,
text "Differential binding to ldl receptor related protein" ,
version 0 ,
refs {
pmid 11811950 } ,
create-date
str "Feb 14 2002 12:00AM" ,
update-date
str "Mar 4 2002 7:46AM" } ,
{
type generif ,
heading "HIV-1 protein interactions" ,
version 0 ,
comment {
{
type generif ,
text "Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake
and degradation of physiological ligands for LRP, including
alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid
beta-protein" ,
version 0 ,
refs {
pmid 11100124 } ,
comment {
{
type comment ,
label "Tat" ,
accession "NP_057853" ,
version 1 ,
source {
{
src {
db "GeneID" ,
tag
id 155871 } } } } ,
{
type comment ,
accession "NP_000005" ,
version 1 } } ,
create-date
str "May 11 2004 12:48PM" ,
t/data/entrezgene.dat view on Meta::CPAN
{
type generif ,
text "Hepatocyte expression of ABCA1 is central to the lipidation of
newly synthesized apoA-I but also contributes to the lipidation of exogenous
apoA-I." ,
version 0 ,
refs {
pmid 12547832 } ,
create-date
str "Apr 2 2003 12:00AM" ,
update-date
str "May 11 2003 7:05AM" } ,
{
type generif ,
text "Golgi is involved in ABCA1-mediated cholesterol efflux." ,
version 0 ,
refs {
pmid 12551894 } ,
create-date
str "Apr 1 2003 12:00AM" ,
update-date
str "May 11 2003 7:05AM" } ,
{
type generif ,
text "ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux
is promoted by central helices of ApoA-I; amino acid residues 220-231 of the
wild-type ApoA-I are required for lipid efflux and high density lipoprotein
formation" ,
version 0 ,
refs {
pmid 12488454 } ,
create-date
str "Mar 20 2003 12:00AM" ,
update-date
str "Apr 13 2003 7:04AM" } ,
{
type generif ,
text "annexin I is externalized from pituitary folliculo-stellate cells
by an ABC transporter and the ATP binding cassette transporter A1 is a likely
candidate" ,
version 0 ,
refs {
pmid 12586783 } ,
create-date
str "Mar 19 2003 12:00AM" ,
update-date
str "Mar 31 2003 6:34AM" } ,
{
type generif ,
text "ATP-binding-cassette transporter A1 gene expression in macrophages
is downregulated by statins" ,
version 0 ,
refs {
pmid 15033469 } ,
create-date
str "Apr 26 2004 12:00AM" ,
update-date
str "May 23 2004 7:05AM" } ,
{
type generif ,
text "ABCA1 is regulated by PEST sequence-mediated calpain proteolysis
that appears to be reversed by apolipoprotein-mediated phospholipid efflux" ,
version 0 ,
refs {
pmid 12511593 } ,
create-date
str "Feb 7 2003 12:00AM" ,
update-date
str "Mar 9 2003 7:04AM" } ,
{
type generif ,
text "REVIEW: ATP-binding cassette transporter A1 and cholesterol
trafficking" ,
version 0 ,
refs {
pmid 12151852 } ,
create-date
str "Jan 24 2003 12:00AM" ,
update-date
str "Feb 2 2003 7:50AM" } ,
{
type generif ,
text "mediates cholesterol efflux and is defective in free
cholesterol-loaded macrophages; mechanism involves enhanced degradation and
full npc1 activity." ,
version 0 ,
refs {
pmid 12215451 } ,
create-date
str "Jan 16 2003 12:00AM" ,
update-date
str "Feb 9 2003 7:14AM" } ,
{
type generif ,
text "induction as a result of liver X receptor agonism increases
secreted Abeta levels" ,
version 0 ,
refs {
pmid 12384498 } ,
create-date
str "Jan 9 2003 12:00AM" ,
update-date
str "Feb 2 2003 7:50AM" } ,
{
type generif ,
text "Increased hepatobiliary and fecal cholesterol excretion upon
activation of the liver X receptor is independent of ABCA1." ,
version 0 ,
refs {
pmid 12105210 } ,
create-date
str "Nov 20 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:50AM" } ,
{
type generif ,
text "A novel serine (Ser-2054) on the ABCA1 protein crucial for PKA
phosphorylation and for regulation of ABCA1 transporter activity." ,
version 0 ,
refs {
pmid 12196520 } ,
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