view release on metacpan or  search on metacpan

scripts/Data/psi-mi.obo  view on Meta::CPAN

id: MI:2039
name: smiles string
def: "SMILES string corresponding to drug structure" [PMID:14755292]
subset: Drugable
is_a: MI:2091 ! structure representation attribute name

[Term]
id: MI:2040
name: drug type
def: "Type of drug (approved, experimental, biotech, nutraceutical)" [PMID:14755292]
subset: Drugable
is_a: MI:2089 ! bioactive entity attribute name

[Term]
id: MI:2041
name: drug category
def: "Therapeutic category or general category of drug (anti-convulsant, antibacterial, etc.)." [PMID:14755292]
subset: Drugable
is_a: MI:2089 ! bioactive entity attribute name

[Term]
id: MI:2042
name: disease indication
def: "Description or common names of diseases that the drug is used to treat." [PMID:14755292]
comment: Source of further terms could be MeSH term or SNOWMAN.
subset: Drugable
is_a: MI:2089 ! bioactive entity attribute name

[Term]
id: MI:2043
name: pharmacology
def: "Text description of how the drug works at a clinical or physiological level." [PMID:14755292]
subset: Drugable
is_a: MI:2089 ! bioactive entity attribute name

[Term]
id: MI:2044
name: mechanism of action
def: "Description of how the drug works or what it binds to at a molecular level." [PMID:14755292]
subset: Drugable
is_a: MI:2089 ! bioactive entity attribute name

[Term]
id: MI:2045
name: drug absorption
def: "Determination of how quickly and how much of a drug reaches its intended target (site) of action." [PMID:14755292]
subset: Drugable
is_a: MI:0640 ! parameter type

[Term]
id: MI:2046
name: lethal dose 50
def: "The LD50 is the dose that kills half (50%) of the animals tested" [PMID:14755292]
subset: Drugable
synonym: "ld50" EXACT PSI-MI-alternate []
synonym: "lethal dose 50 %" EXACT PSI-MI-alternate []
is_a: MI:0640 ! parameter type

[Term]
id: MI:2047
name: percentage of plasma protein binding
def: "Percentage of the drug that is bound in plasma proteins" [PMID:14755292]
subset: Drugable
synonym: "plasma prot binding" EXACT PSI-MI-short []
synonym: "protein binding %" EXACT PSI-MI-alternate []
is_a: MI:0640 ! parameter type

[Term]
id: MI:2048
name: drug biotransformation
def: "The chemical conversion of drugs to other compounds in the body, excluding degradation due to any inherent chemical instability of drugs in biological media." [PMID:14755292]
subset: Drugable
synonym: "drug metabolism" EXACT PSI-MI-short []
is_a: MI:2115 ! pharmacokinetics attribute name

[Term]
id: MI:2049
name: elimination half life
def: "Rate The time it takes for the body to eliminate or breakdown half of a dose of a pharmacologic agent, in practice the time taken for plasma concentration to reduce by 50%." [PMID:14755292]
subset: Drugable
synonym: "distribution halflife" EXACT PSI-MI-alternate []
synonym: "elimin half life" EXACT PSI-MI-short []
synonym: "t1/2" EXACT PSI-MI-alternate []
is_a: MI:0640 ! parameter type

[Term]
id: MI:2050
name: dosage form
def: "How the drug is dispensed (tablets, capsules, solutions), packing material." [PMID:14755292]
subset: Drugable
is_a: MI:2089 ! bioactive entity attribute name

[Term]
id: MI:2051
name: patient information
def: "Information on the disease indications and treatment regime for the drug. May also include contra-indications." [PMID:14755292]
subset: Drugable
is_a: MI:2089 ! bioactive entity attribute name

[Term]
id: MI:2053
name: contraindications
def: "Cautions or conditions indicating why or when the drug should not be taken or prescribed." [PMID:14755292]
subset: Drugable
is_a: MI:2089 ! bioactive entity attribute name

[Term]
id: MI:2054
name: bioactive entity reference
def: "General on-line reference to other details about a drug or other bioactive entity." [PMID:14755292]
subset: Drugable
subset: PSI-MI slim
synonym: "bioactive entity ref" EXACT PSI-MI-short []
is_a: MI:0473 ! participant database

[Term]
id: MI:2055
name: chemical stability
def: "chemical stability occurs when a substance is in a (dynamic) chemical equilibrium with its environment. In this well-defined state, the substance is expected to persist indefinitely (assuming that the environment does not change).  A substance ...
subset: Drugable
synonym: "thermodynamic stability" EXACT PSI-MI-alternate []